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Hot Rainy Saturday Reading July 30

Dreaming up new proteins, AI churns out possible medicines and vaccines

Instead of predicting the shapes of naturally occurring molecules, software designs original ones

Dreaming up new proteins, AI churns out possible medicines and vaccines | Science | AAAS

‘Gold mine of unexplored biology’: Short protein sequences could dramatically expand human genome

New consortium will vet whether 7000-plus RNAs make stable proteins with cellular functions

‘Gold mine of unexplored biology’: Short protein sequences could dramatically expand human genome | Science | AAAS

Unpicking the link between smell and memories

The ability of aromas to bring back highly specific memories is becoming better understood, and could be used to boost and heal our brains.

Unpicking the link between smell and memories (nature.com)

With AAV alternative and DNA writing tech, a new hub-and-spoke startup wants to ‘democratize’ gene therapies

With AAV alternative and DNA writing tech, a new hub-and-spoke startup wants to ‘democratize’ gene therapies – Endpoints News (endpts.com)

We’re starting to understand the mysterious surge of hepatitis in children

Lockdowns, genes, and viruses that hide in our cells all appear to have played a role.

We’re starting to understand the mysterious surge of hepatitis in children | MIT Technology Review

The Man Who Would Be a Machine

Peter Scott-Morgan had A.L.S. and hoped that, by using himself as a test subject, he could help the cause of others.

The Man Who Would Be a Machine | The New Yorker

Reactivating Type 1 diabetics’ pancreatic stem cells to produce insulin

Reactivated diabetic pancreatic stem cells produce insulin (cosmosmagazine.com)

Researchers revive abandoned technique in effort to make artificial human eggs in a test tube

Researchers launch effort to make artificial human eggs in test tube - STAT (statnews.com)

DeepMind has predicted the structure of almost every protein known to science

And it’s giving the data away for free, which could spur new scientific discoveries.

DeepMind has predicted the structure of almost every protein known to science | MIT Technology Review

James Lovelock, a gentleman scientist

Philip Ball reflects on the legacy of the creator of the Gaia hypothesis, who has died aged 103

James Lovelock, a gentleman scientist | Opinion | Chemistry World

Closing the loop for patients with Parkinson disease: where are we?

Closing the loop for patients with Parkinson disease: where are we? | Nature Reviews Neurology

The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic

The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic | Nature Reviews Neurology

Bioprinting-assisted tissue assembly to generate organ substitutes at scale

Bioprinting-assisted tissue assembly to generate organ substitutes at scale: Trends in Biotechnology (cell.com)

Neuronal Scaffolding Plays Unexpected Role in Pain

Perineuronal nets, rigid structures that hold certain neurons in place, affect a surprising amount of brain activity, including some associated with chronic pain.

Neuronal Scaffolding Plays Unexpected Role in Chronic Pain | Quanta Magazine

By exploiting the DNA repair system, Yale scientists want to crack chemotherapy resistant brain cancer

By exploiting the DNA repair system, Yale scientists want to crack chemotherapy resistant brain cancer – Endpoints News (endpts.com)

Rejuvenating the human gut microbiome

Rejuvenating the human gut microbiome: Trends in Molecular Medicine (cell.com)

RNAi for common diseases? Alnylam plans to forge a path forward, starting with new obesity gene target

RNAi for common diseases? Alnylam plans to forge a path forward, starting with new obesity gene target – Endpoints News (endpts.com)