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Summer Weekend Reading July 2nd

Another Astellas gene therapy trial paused by FDA after side effect report

Another Astellas gene therapy trial paused by FDA after side effect report | BioPharma Dive

What Omicron’s BA.4 and BA.5 variants mean for the pandemic

The lineages’ rise seems to stem from their ability to infect people who were immune to earlier forms of Omicron and other variants.

What Omicron’s BA.4 and BA.5 variants mean for the pandemic (nature.com)

Manipulating T-cell fate to improve CAR-T therapy in solid tumors

Manipulating T cell fate to improve CAR-T in solid tumors (fiercebiotech.com)

How to make spatial maps of gene activity — down to the cellular level

Computational and experimental methods are bringing researchers closer to their goal of revealing exactly where in a cell or tissue each gene is expressed.

How to make spatial maps of gene activity — down to the cellular level (nature.com)

Protein Blobs Linked to Alzheimer’s Affect Aging in All Cells

Protein buildups like those seen around neurons in Alzheimer’s, Parkinson’s and other brain diseases occur in all aging cells, a new study suggests. Learning their significance may reveal new strategies for treating age-related diseases.

Protein Blobs Linked to Alzheimer’s Affect Aging in All Cells | Quanta Magazine

J&J-backed gene therapy for the eye clears early study test

J&J-backed gene therapy for the eye clears early study test | BioPharma Dive

U.K. set to abandon Europe’s top science funding program, go it alone

As Brexit dispute deepens, grant winners forced to reject money or move to Europe

U.K. set to abandon Europe’s top science funding program, go it alone | Science | AAAS

Novel CD19 chimeric antigen receptor T cells manufactured next-day for acute lymphoblastic leukemia

Novel CD19 chimeric antigen receptor T cells manufactured next-day for acute lymphoblastic leukemia | Blood Cancer Journal (nature.com)

The microbiome and gut homeostasis

The microbiome and gut homeostasis (science.org)

Fierce Next Gen: As gene therapies proliferate, pharma and payers look to avoid 'cost shocks'

As gene therapies proliferate, a risk of 'cost shock' looms (fiercepharma.com)

Bayer, Amgen back ReCode's plan to broaden genetic medicine's reach

The two drugmakers, through their venture arms, join a long list of investors already supporting the startup.

Bayer, Amgen back ReCode's plan to broaden genetic medicine's reach | BioPharma Dive