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Christmas Eve Weekend Reading Dec 24

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours | Nature Reviews Clinical Oncology

‘We’ve never had a technology like Crispr before’: gene-editing moves into the clinic

Crispr moves into the clinic | News | Chemistry World

EC approves first allogeneic T cell therapy for rare post-transplant complication

EC approves first allogeneic T cell therapy for rare post-transplant complication – Endpoints News (endpts.com)

After prior rejection, Ferring finally nabs FDA nod for bladder cancer gene therapy

After prior rejection, Ferring finally nabs FDA nod for bladder cancer gene therapy | Fierce Pharma

Kite swoops in to buy Carl June-founded Tmunity, gaining key to Penn's CAR-T research apparatus

Gilead's Kite swoops in to buy CAR-T focused Tmunity (fiercebiotech.com)

Cancer center leaders lay bare CAR-T makers' struggles—and an unexpected laggard

Cancer center leaders lay bare CAR-T makers’ struggles (fiercepharma.com)

New Biomarker Found That Could Potentially Aid Early Screening for Dementia

New Biomarker Found That Could Potentially Aid Early Screening for Dementia | Inside Precision Medicine

Emerging immunomodulatory strategies for cell therapeutics

Emerging immunomodulatory strategies for cell therapeutics: Trends in Biotechnology

Challenges and opportunities in bringing nonbiological atoms to life with synthetic metabolism

Challenges and opportunities in bringing nonbiological atoms to life with synthetic metabolism: Trends in Biotechnology (cell.com)

In a first, children with rare genetic diseases get mitochondrial transplants from their mothers

Kids with rare diseases get mitochondria from their mothers - STAT (statnews.com)

Scientists Created Male and Female Cells from a Single Person

Cells with XX or XY chromosomes provide researchers with a new tool to study how differences in sex chromosomes can influence health and development

Scientists Created Male and Female Cells from a Single Person - Scientific American

Brain Monitoring Could Prevent Most Neurological and Psychiatric Illnesses

By crunching data from molecular tests, cognitive assessments and medical history, doctors could one day intervene and prevent brain disease.

Brain Monitoring Could Prevent Most Neurological and Psychiatric Illnesses - Scientific American

Gene therapy restored immune system in children with rare disorder

10 children with the rare condition Artemis-deficient severe combined immunodeficiency had their immune systems either partially or fully restored with gene-replacement therapy

SCID: Gene therapy restored immune system in children with rare disorder | New Scientist

Scientists tie third clinical trial death to experimental Alzheimer’s drug

Amid lobbying for lecanemab’s approval, a newly revealed death adds to doubts about safety of anti-amyloid antibody

Scientists tie third clinical trial death to experimental Alzheimer’s drug | Science | AAAS