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Late Autumn Weekend Reading Nov 19

Alzheimer's treatment hopes take another dive as Roche drug fails trial, Next-generation brain observatories, Inside the billion-dollar meeting for the mega-rich who want to live forever, How the hydrogen revolution can help save the planet — and how it can’t, Major advances in Parkinson's disease over the past two decades and future research directions, Neurology, Imaging of the optic nerve, Bacteria in tumors may promote cancer, This is how an Alzheimer’s gene ravages the brain, Editas halts lead CRISPR program after efficacy data underwhelm, The circular economy – Nature Outlook
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Late Nov Weekend Reading Nov 26

Maker of new gene therapy vector launches its second company, looking to zero in on rare skin conditions, Turns Out Fighting Mosquitoes With Mosquitoes Actually Works, Rethinking cancer targeting strategies in the era of smart cell therapeutics, FDA approves first gene therapy for hemophilia B, The future of animal-to-human transplants, A French Village’s Radical Vision of a Good Life with Alzheimer’s, Every resident of the Village Landais has dementia—and the autonomy to spend each day CRISPR tools found in thousands of viruses could boost gene editing, The future of engineered immune cell therapies, The emerging era of cell engineering: Harnessing the modularity of cells to program complex biological function, Ethics guidelines for human enhancement R&D, COVID-19 Triggers Brain Inflammation Similar to Parkinson’s and Other Neurodegenerative Conditions, We can now use cells from dead people to create new life. But who gets to decide?
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National Happy Hour Day Reading Nov 12

New hope for sickle cell patients as UK trial of lab grown red blood cells begins, Mapping brain genes in autism finds widespread changes, especially in visual regions, Adaptimmune to lay off up to 30% of staff as allogeneic ambitions stunted by cell line change, Two former Stanford researchers nab a $41M launch round to learn the secrets of the ‘secretome’, Mining from plants and fungi, CNS startup takes leap into psychoactive drugs — complete with $30M to kick things off, Brain implants that translate paralyzed patients’ thoughts into speech creep closer to reality, Unlocking the promise of mRNA therapeutics, Psychedelics and Neural Plasticity: Therapeutic Implications, Electrical stimulation helps paralysed people walk again, Challenges in neoantigen-directed cancer therapeutics, In a first, a fatal enzyme deficiency is treated in the womb, Improving antitumor T cells, CRISPR cancer trial success paves the way for personalized treatments
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Happy Bonfire Night Weekend Reading Nov 5

Human cerebral organoids — a new tool for clinical neurology research, A single injection of Unity's anti-aging hypothesis bears fruit in PhII, as pivotal plans shape up, Engineers look to nature for ideas on how to make robots move through the world, CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities, Bioelectronic medicine: Preclinical insights and clinical advances, Allogene completes Shanghai facility to manufacture CAR-T products, The shape-shifting blobs that shook up cell biology, After the First Pig-to-Human Heart Transplant, Scientists Look to the Future of Cardiac Xenotransplantation, Here’s why we’re not prepared for the next wave of biotech innovation, A brain-computer interface deciphers commands intended for the vocal tract, Microbial molecules from soil, seawater and human bodies are among the planet’s least understood, New Nanoparticle Technology Triggers Immune Response in Cancer, Reciprocal regulation of mesenchymal stem cells and immune responses, Abeona to submit cell therapy for approval after positive results for skin disorder treatment, Neurological Disorders May Be Treated by Gene Therapy Approach, Here’s how personalized brain stimulation could treat depression
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Light Autumnal Reading Oct 22

Lilly bets more than $600M on a gene therapy developer targeting hearing loss, A stem cell aging framework, from mechanisms to interventions, Healthy aging and the human gut microbiome: why we cannot just turn back the clock, ‘In vivo’ cell therapy: expanding beyond CAR-T, The debate over whether aging is a disease rages on , First known map of night sky found hidden in Medieval parchmen, Black Death may have influenced evolution of genes involved in immune responses, Nucleome raises £37.5m to shine light on ‘dark genome’, Gilead, working to improve cancer cell therapy, partners with California startup
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Fab Indian Summer Reading Oct 15

Meet the company builders that think they can reverse ageing, Clinical advances and ongoing trials of mRNA vaccines for cancer treatment, Immatics spotlights more early data for TCR cell therapy in solid tumors, Tiny delivery systems for cancer drugs, Purifying mesencephalic dopaminergic progenitors differentiated from human pluripotent stem cells, Ageing and multiple sclerosis, With stem cell technology and lab-grown brain organoids, Sergiu Paşca seeks the causes of autism and other neuropsychiatric conditions, Rat–human hybrid brains offer new ways to study human neurological disorders, but also raise ethical questions, The field of artificial intelligence (AI) and robotics research is expanding at a rapid rate, Male Birth Control Is in Development, but Barriers Still Stand in the Way, The Search for a pill that can help dogs and humans live longer, Faster brain imaging technique seems to overcome limitations of current MRI scans, Why the sci-fi dream of cryonics never died
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Light Early Autumnal Reading Oct 8

Is the body key to understanding consciousness?, Self-Taught AI May Have a Lot in Common With the Human Brain, After $100M deal, J&J links gene therapy to improved vision in early-phase trial, MIT team develops burrowing robotic pill to break through the intestine's drug-blocking mucus, A Bold Effort to Cure HIV—Using Crispr, CAR NK Cell Activity Improved via Novel Engineering Approach, Will there be a COVID winter wave? What scientists say, Alzheimer’s drug slows mental decline in trial — but is it a breakthrough?, Do fungi lurking inside cancers speed their growth?, Allogene gets green light for pivotal CAR-T trial, starts industry’s first off-the-shelf phase 2
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Early Autumn Weekend Reading Oct 1

Clinical advances and ongoing trials on mRNA vaccines for cancertreatment , Genentech pays $70M to access Arsenal's armory of T-cell tools in questfor solid tumor CAR-TGenentech pays $70M to access Arsenal's armory of T-cell tools, Sanofi pays Scribe $25M to access CRISPR tools, George Church’s woolly mammoth revival biotech Colossal spins out computational bio outfit, Could Alzheimer’s be an autoimmune disease?, Alzheimer’s drug from Eisai, Biogen shows benefit in large trialIn surprise result, Coffee Linked to Reduced Cardiovascular Disease and Mortality, A bionic pancreas aims to take the math out of managing type 1 diabetes, Psychedelic medicine, Cell and gene therapies from academia, Big COVID-19 waves may be coming, new Omicron strains suggest
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International Rabbit Day Reading Sept 24

After decades of merely assisting doctors, are sophisticated machines ready to take charge?, Company reports first benefits to patients from injecting the molecular gene-editing tool into the blood, The therapy, cleared to treat cerebral adrenoleukodystrophy, is the product of more than a decade of work by Bluebird. It will cost $3 million., Ambitious $746 million program aims to complement big neuroscience projects in Europe and the United States, Some companies offer tests that rank embryos based on their risk of developing complex diseases such as schizophrenia or heart disease. Are they accurate — or ethical?, Will quantum computing be a massive breakthrough for the pharma industry? Or is it all just hype?, There’s New Proof Crispr Can Edit Genes Inside Human Bodies, FDA advisers back microbiota-based treatment for gut infection
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Slovenian Monsoon Season Reading Sept 17

New private venture tackles the riddle of Long Covid—and aims to test treatments quickly, ESMO: BioNTech's CAR-T response rate falls in fresh cut of early-phase data, Verily raises $1bn to push ahead with precision health plans, Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma, Forge Biologics continues its hot streak with $90M round to boost gene therapy manufacturing services Akero hits endpoints in midphase NASH trial, linking candidate to improvements in fibrosis, Europe’s Drought Might Force Acceptance of Gene-Edited Crops, Treatment of Genetic Diseases With CRISPR Genome Editing, SparingVision raises €75m for eye disease gene therapies
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Light Early Autumnal Weekend Reading Sept 10

Born without my left temporal lobe, a brain region thought to be critical for language, A memory prosthesis could restore memory in people with damaged brains, BMS-backed Arsenal Bio pulls trigger on $220M series B, touting potential fleet of gene-edited cell therapies, Embryos with DNA from three people develop normally in first safety study, Smart software untangles gene regulation in cells, Beam-linked startup launches with an eye on the next generation of RNA drugs, Prehistoric child’s amputation is oldest surgery of its kind, New malaria vaccine shows high efficacy, yields high hopes, ‘Breakthrough’ finding shows how modern humans grow more brain cells than Neanderthals, Deerfield backs a Penn spinout aiming to shake up Parkinson's treatments using stem cells
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International Vulture Awareness Day Reading Sept 3

Flexible organic circuits that mimic biological neurons could increase processing speed, The role of the gut microbiota in multiple sclerosis, Hybrid brains – the ethics of transplanting human neurons into animals, Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL, A new gene therapy based on antibody cells is about to be tested in humans, Landscape of cancer cell therapies: trends and real-world data, Engineering the next generation of cell-based therapeutics
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World Honey Bee Day Reading Aug 20

Anti-aging drugs trialled in companion dogs, Blood abnormalities found in people with Long Covid, Implanted devices let people control computers and prosthetic limbs with their minds, Epigenetic ‘Clocks’ Predict Animals’ True Biological Age, Cellular senescence and senolytics: the path to the clinic, Which COVID boosters to take and when: a guide for the perplexed
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Light Summer Dog Days Reading Aug 13

Sarepta licenses next-gen AAV tech from Broad Institute in deal covering five indications — including Duchenne, A Biochemist’s View of Life’s Origin Reframes Cancer and Aging, Vector BioPharma Launches With Novel Gene Delivery Platform, Charting the next century of insulin replacement with cell and gene therapies, Promises and challenges of organoid-guided precision medicine, A Beer a Day May Boost Your Gut MicrobiomeA Beer a Day May Boost Your Gut Microbiome, Two deaths after Novartis' Zolgensma put gene therapy’s liver safety in the spotlight once again, A bioengineered cornea can restore sight to blind people
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Hiroshima Peace Day Reading Aug 6

U.K. charity gives $36 million boost to gene editing for inherited heart diseases, AAAS Gut Metabolite from Red Meat Consumption Implicated in Heightened Cardiovascular Disease Risk, Cognito’s light-and-sound therapy slows brain tissue atrophy in Alzheimer’s study, The Age of Brain-Computer Interfaces Is on the Horizon, Synthetic mouse embryos created from stem cells — without sperm, eggs, or a uterus, New Alzheimer's cell atlas points to potential drug targets, Hybrid brains: the ethics of transplanting human neurons into animals, ElevateBio, Boston Children’s launch startup to test new approach to ‘off-the-shelf’ cell therapy, Modifying “Native” Gut Bacteria Could Treat Chronic Disease, Individual genetic factors could lead to customized cardiac therapies
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Hot Rainy Saturday Reading July 30

AI churns out possible medicines and vaccines, Short protein sequences could dramatically expand human genome, Reactivating Type 1 diabetics’ pancreatic stem cells to produce insulin, Researchers revive abandoned technique in effort to make artificial human eggs in a test tube
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Scorching Hot Weekend Reading July 23

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells, A modular strategy for next-generation upper-limb sensory-motor neuroprostheses, CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers, Recommendations of the Nutrition for Dementia Prevention, CRISPR ‘cousin’ put to the test in landmark heart-disease trial, New EU rules on blood, tissue, cells to be adapted to evolving science, Gene therapy for ovarian cancer fails PhIII study, Embryonic Research Could Be the Next Target After Roe, Restoring hearing with beams of light
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Really Light Weekend Reading July 15

Fecal transplants treating gut diseases, Edits to a cholesterol gene could stop the biggest killer on earth, Labcorp launches blood test for a wide range of neurodegenerative diseases and brain injuries, Newly Recognized Dementia Called LATE May Hit 40 Percent of Older People, The radical plan for vaccine equity
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Lazy Summer Weekend Reading July 9

Sir Colin Blakemore obituary, Vertex's Type 1 diabetes cell therapy heads back to clinic after FDA hold lifted, Therapeutic in vivo delivery of gene editing agents, Recreating the heart’s helical structure-function relationship with focused rotary jet spinning, Clinical trials for pig-to-human organ transplants inch closer, Webb’s Fine Guidance Sensor Provides a Preview
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Summer Weekend Reading July 2nd

Another Astellas gene therapy trial paused by FDA after side effect report, What Omicron’s BA.4 and BA.5 variants mean for the pandemic, Manipulating T-cell fate to improve CAR-T therapy in solid tumors, How to make spatial maps of gene activity — down to the cellular level, Protein Blobs Linked to Alzheimer’s Affect Aging in All Cells, J&J-backed gene therapy for the eye clears early study test, U.K. set to abandon Europe’s top science funding program, Novel CD19 chimeric antigen receptor T cells manufactured next-day for acute lymphoblastic leukemia, The microbiome and gut homeostasis, Fierce Next Gen: As gene therapies proliferate, pharma and payers look to avoid 'cost shocks', Bayer, Amgen back ReCode's plan to broaden genetic medicine's reach
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Hot Summer Weekend Reading June 25

The clinical progress of mRNA vaccines and immunotherapies, Regenerative and restorative medicine for eye disease, Leveraging technology to personalize cognitive enhancement methods in aging, Carbon Biosciences emerges with a new viral vector to shake up the cystic fibrosis gene therapy field, Single MRI-based brain scan could diagnose Alzheimer’s disease, says study, Center for Breakthrough Medicines plans for an even larger dive into cell therapy manufacturing, In pursuit of accessible sickle cell cure, Novartis inks $1.5B deal to tap Precision's ARCUS gene editing tech, Galapagos finally takes M&A plunge, spending $251M for 2 biotechs in CAR-T push, Nature Outlook - Smell, The joint battle to tackle epidermolysis bullosa through gene therapy, BioNTech's solid tumor CAR-T hits prime time with EU regulatory tag, Sanofi, GSK say dual-acting vaccine prevents COVID-19 from omicron in large trial, Little-known OrbiMed-backed biotech closes $160M round to start gene therapy trial
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Lazy Weekend Reading June 18

Cancer vaccines, Vertex, CRISPR strengthen case for pioneering gene-editing treatment, CAR T-Cell Therapy Shows Early Promise for Gastrointestinal Cancer, A $100 genome? New DNA sequencers could be a ‘game changer’ for biology, medicine, The human microbiome: there is much left to do, Roche Alzheimer’s study fails in another setback to a long-tested hypothesis, Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials, Ancient DNA traces origin of Black Death
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